Burden Of Disease

- Acute Kidney Disease (AKI) is an abrupt loss of kidney function.
- Loss of kidney blood flow (kidney ischemia) is a leading cause of AKI
- The consequences of are severe
- Short-term consequences include anuria, hyperkalemia, and metabolic dysfunction
- Long-term consequences are CKD, dialysis dependence and may include death
- Current medical response consists of supportive care
- Kidney function does not return in most AKI patients

Incidence of AKI in the United States

There are more than 8 million annual cases (incidence) of AKI in the U.S. - 80,000 will require dialysis. AKI frequently occurs after cardiac and other thoracic/abdominal surgeries in patients that can be identified at high risk for AKI.

Greatly increases hospital re-admissions and number of days in intensive care.

Mortality in patients experiencing AKI has been shown in studies to be as high as 40%.

Economic Impact of AKI

In the United States, annual direct costs of AKI are about $24 billion, which does not include the costs of dialysis & transplant following End-Stage Renal Disease (ESRD)

In the United Kingdom, AKI consumes 1% of the entire NHS budget.

Our target AKI market, focused only on easily identified high risk patients currently exceeds $8 billion annually

AKI is a high priority for both national and international advocacy groups including the National Kidney Foundation, the American Society for Nephrology and the International Society for Nephrology